Design, synthesis, and computational affinity prediction of ester soft drugs as inhibitors of dihydrofolate reductase from Pneumocystis carinii

Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function

Garrett M. Morris, David S. Goodsell, Robert S. Halliday et al. · Journal of Computational Chemistry · 1998 · 10.8K citations

Life Sciences, Bioinformatics, Molecular Biology +17

A new method for predicting binding affinity in computer-aided drug design

Johan Åqvist, Carmen Medina, Jan-Erik Samuelsson · Protein Engineering Design and Selection · 1994 · 1.2K citations

Pharmacy, Biophysics, Medicinal Chemistry +17

<i>Pneumocystis carinii</i> Pneumonia: A Comparison Between Patients with the Acquired Immunodeficiency Syndrome and Patients with Other Immunodeficiencies

Joseph A. Kovacs · Annals of Internal Medicine · 1984 · 856 citations

Medicine, Infectious Diseases, Internal Medicine +10

Adverse Reactions to Trimethoprim-Sulfamethoxazole in Patients with the Acquired Immunodeficiency Syndrome

Fred M. Gordin · Annals of Internal Medicine · 1984 · 708 citations

Medicine, Infectious Diseases, Pharmacology +10

Safety and efficacy of sulfamethoxazole and trimethoprim chemoprophylaxis for Pneumocystis carinii pneumonia in AIDS

Margaret A. Fischl · JAMA · 1988 · 430 citations

Medicine, Infectious Diseases, Pharmacology +17