Concepedia

Protective effects of erythropoietin in traumatic spinal cord injury by inducing the Nrf2 signaling pathway activation

Wei Jin, Xing Ming, Xiaoshan Hou, Tiansheng Zhu, Baoyu Yuan, Jing Wang, Hongbin Ni, Jian Jiang, Handong Wang, Weibang Liang

The Journal of Trauma: Injury, Infection, and Critical Care · 2014 · 33 citations · 30 references

DOI

Abstract

Post-SCI rhEPO administration induces Nrf2-mediated cytoprotective response in the injured spinal cord, and this may be a mechanism whereby rhEPO improves the outcome following SCI.

References

30

Erythropoietin crosses the blood–brain barrier to protect against experimental brain injury

Michael Brines, Pietro Ghezzi, Sonja Keenan et al. · Proceedings of the National Academy of Sciences · 2000 · 1.4K citations · Full text

Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress

Anna‐Leena Sirén, Maddalena Fratelli, Michael Brines et al. · Proceedings of the National Academy of Sciences · 2001 · 1K citations · Full text

Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-κB signalling cascades

Murat Digicaylioglu, Stuart A. Lipton · Nature · 2001 · 928 citations

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Erythropoietin prevents motor neuron apoptosis and neurologic disability in experimental spinal cord ischemic injury

Murat Çeli̇k, Necati Gökmen, Serhat Erbayraktar et al. · Proceedings of the National Academy of Sciences · 2002 · 476 citations · Full text

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Erythropoietin Enhances Neurogenesis and Restores Spatial Memory in Rats after Traumatic Brain Injury

Dunyue Lu, Asim Mahmood, Changsheng Qu et al. · Journal of Neurotrauma · 2005 · 264 citations

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