Virus-Free Adenocarcinoma of the Frog (Summer Phase Tumor) Transcribes Lucké Tumor Herpesvirus-Specific RNA

Abstract

[(3)H]RNA isolated from "virus-free," summer phase, renal adenocarcinomas of Rana pipiens labeled with [(3)H]uridine hybridizes with DNA of herpesvirus particles isolated from the winter phase Lucké tumor. Transcription of the herpesvirus genome in virus-free tumors provides additional evidence for the viral etiology of this tumor.