Planta Medica · 1988 · 20 citations · 0 references
MedicineInfectious DiseasesOphthalmologyOcular ImmunologyOcular MicrobiologyOcular PharmacologyCorneal InfectionHerpetic Eye DiseaseOcular Antimicrobial TherapyOphthalmic OintmentsRabbit OphthalmologyVeterinary Ocular PharmacologyActive Compound IsolationAnti-infective Ocular Drug EffectsAntiviral TherapeuticsAntiviral TreatmentHerpes Simplex KeratitisHerpetic Eye Disease TreatmentInoculationRabbit Models
Herpetic keratitis induced in rabbit eyes was experimentally treated with triterpene saponins from Anagallis arvensis (Primulaceae) and antiviral drugs: idoxuridine, adenine arabinoside, and acycloguanosine. Saponin ointment appeared to be as effective as adenine arabinoside and from days 10 to 14 post inoculation was better than idoxuridine; the most active compound being acycloguanosine.