Synthesis of Neu5Ac Oligosaccharides and Analogues by Transglycosylation and their Binding Properties as Ligands to MAG

Abstract

A trans-sialidase from Trypanosoma cruzi was used to prepare several sialic acid-containing oligosaccharides with a truncated glycerol side chain. STD NMR was used to characterise the binding constant and binding epitope of the oligosaccharides to their neural receptor protein MAG. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2268/2006/z500543_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.