Structural Studies on the Carbohydrate Portion of Human alpha1-Microglobulin

Abstract

Human alpha 1-microglobulin has been shown to have three N-glycosidically linked carbohydrate chains of the following structure: (formula: see text) This structure was established by sugar and methylation analysis before and after removal of the N-acetylneuraminic acid residue and by using specific chemical degradation techniques such as Smith degradation, chromium trioxide oxidation and trifluoroacetolysis.