Characterization of purified autoantibodies to the insulin receptor from six patients with type B insulin resistance

Isolation of pure IgG1, IgG2a and IgG2b immunoglobulins from mouse serum using protein A-Sepharose

Peter L. Ey, Stephen J. Prowse, C. R. Jenkin · Immunochemistry · 1978 · 2.7K citations

Life Sciences, Biochemistry, Biotechnology +13

The Syndromes of Insulin Resistance and Acanthosis Nigricans

C. Ronald Kahn, Jeffrey S. Flier, Robert S. Bar et al. · New England Journal of Medicine · 1976 · 1.1K citations

Medicine, Endocrinology, Immunology +13

Antibodies That Impair Insulin Receptor Binding in an Unusual Diabetic Syndrome with Severe Insulin Resistance

Jeffrey S. Flier, C. Ronald Kahn, Jesse Roth et al. · Science · 1975 · 440 citations

Medicine, Endocrinology, Immunology +15

Two Mutant Alleles of the Insulin Receptor Gene in a Patient with Extreme Insulin Resistance

Takashi Kadowaki, Charles Bevins, Alessandro Cama et al. · Science · 1988 · 313 citations

Medicine, Endocrinology, Genetics +15

Effects of Autoantibodies to the Insulin Receptor on Isolated Adipocytes

C. Ronald Kahn, Kathleen L. Baird, Jeffrey S. Flier et al. · Journal of Clinical Investigation · 1977 · 245 citations · Full text

Medicine, Endocrinology, Immunology +17