Immunohistologic analysis of renal CD40 and CD40L expression in lupus nephritis and other glomerulonephritides

Abstract

This study shows that CD40 is expressed on a variety of renal parenchymal and non-parenchymal cells in normal kidney. Renal CD40 expression is up-regulated in class III and class IV lupus nephritis, as well as in other inflammatory renal diseases, and is associated with the presence of CD40L+ mononuclear cells.