The Nephron journals/Nephron journals · 2008 · 12 citations · 0 references
MedicineNephrologySurgeryCalcium HomeostasisKidney TransplantationMineral MetabolismCalcium MetabolismIntestinal Calcium AbsorptionIntestinal Mineral AbsorptionNutrient AbsorptionPhosphate HomeostasisVitamin D MetabolismIntestinal Phosphate AbsorptionIntestinal Vitamin D AbsorptionNutrient Absorption DisordersNutritional MalabsorptionRenal Phosphate TransportTransplantationVitamin D Metabolism ImpairmentVitamin D-dependent Calcium Absorption
After successful renal transplantation there is continuing malabsorption of calcium and phosphorus. This is due in part to impaired glomerular filtration rate, and in part to the action of steroid on calcium and phosphorus absorption. The effect of steroids is most marked over the first 18 months after transplantation and causes significant malabsorption of calcium and phosphorus even though good graft function is established. Calcium and phosphorus malabsorption can be improved by exogenous 1,25-dihydroxy vitamin D (oral 1 alpha-OH D3 or 1,25-[OH]2D3).