Basophil Chemotaxis: Augmentation by a Factor from Stimulated Lymphocyte Cultures

Abstract

Normal human basophil leukocytes have been found to respond chemotactically in vitro to lymphocyte-derived (LDCF) or complement-derived (C5a) chemotactic factors. In addition, preincubation of basophils with LDCF augmented their subsequent response to C5a. This effect was not observed after preincubation with unstimulated lymphocyte supernatants, C5a, or medium. These findings may help define the mechanism of basophil appearance in delayed cutaneous hypersensitivity reactions.