MicroRNA-141 is downregulated in human renal cell carcinoma and regulates cell survival by targeting CDC25B

Abstract

For the first time, we demonstrated that CDC25B is a direct target of miR-141 in renal cell carcinoma. The transcriptional loss of miR-141 and the resultant increase in CDC25B expression facilitates increased genomic instability at an early stage of renal cell carcinoma development.