Synthesis of Peptides Containing α,α‐Disubstituted α‐Amino Acids by the Azirine/Oxazolone Method: The (12–20)‐Nonapeptide of the Ionophore Alamethicin

Abstract

Abstract The (12–20)‐nonapeptide Z‐Leu‐Aib‐Pro‐Val‐Aib‐Aib‐Glu (OBzl)‐Gln‐Pheol ( 10 ) of the ionophor alamethicin was synthesized by a new strategy, using 3‐amino‐2,2‐dimethyl‐2 H ‐azirines 2 as synthons for the α‐aminoisobutyric acid (Aib) moieties.