Concepedia

Rapamycin as an inhibitor of osteogenic differentiation in bone marrow-derived mesenchymal stem cells

Shinji Isomoto, Koji Hattori, Hajime Ohgushi, Hiroshi Nakajima, Yasuhito Tanaka, Yoshinori Takakura

Journal of Orthopaedic Science · 2007 · 60 citations · 23 references

DOI

Concepts

References

23

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

Jun S. Liu, Jesse D. Farmer, Willam S. Lane et al. · Cell · 1991 · 4.1K citations

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A mammalian protein targeted by G1-arresting rapamycin–receptor complex

Eric J. Brown, Mark W. Albers, Tae Bum Shin et al. · Nature · 1994 · 2.1K citations

, , +11

Bone formation in vitro by stromal cells obtained from bone marrow of young adult rats

C. Maniatopoulos, Jaro Sodek, A. H. Melcher · Cell and Tissue Research · 1988 · 1.3K citations

, , +16

Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity

J. Liu, Mark W. Albers, Thomas J. Wandless et al. · Biochemistry · 1992 · 561 citations

, , +17

The Immunophilin FKBP12 Functions as a Common Inhibitor of the TGFβ Family Type I Receptors

Tongwen Wang, Bi-Yu Li, Paul D. Danielson et al. · Cell · 1996 · 380 citations · Full text

, , +11