<title>Progress toward implantable fluorescence-based sensors for monitoring glucose levels in interstitial fluid</title>

Abstract

A painless monitoring procedure for diabetics has proven to be an elusive goal. While completely noninvasive measurements are the desired technique, minimally invasive procedures using implanted fluorescence sensor chemistry offer significant advantages in specificity over current noninvasive approaches. The goal was to evaluate the potential for transdermal glucose sensing using intensity measurements from implanted microspheres. A fiber-optic probe and spectrometer were custom-built for collection of in vivo data. Comparisons with commercial fluorometers show the constructed device is adequate for this project.