Dendrimeric Gd(iii) complex of a monophosphinated DOTA analogue: optimizing relaxivity by reducing internal motion

Abstract

A marked increase of relaxivity has been observed upon rigidifying the internal frame of Gd-containing PAMAM dendrimers: the effect has been attained by either protonation of the dendrimer or by forming supramolecular adducts with cationic polyaminoacids.