Continuous Enantioselective Hydrogenation with a Molecular Catalyst in Supported Ionic Liquid Phase under Supercritical CO₂ Flow

Abstract

Highly efficient continuous-flow asymmetric catalysis was achieved by combination of supported ionic liquid phase (SILP) catalysts with supercritical CO2 (scCO2) as the mobile phase, as demonstrated for enantioselective hydrogenation in the presence of a molecular rhodium–QUINAPHOS complex. The integrated reaction and separation process yielded chemically and enantiomerically pure products without the need for organic solvents. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.