AUTAPSE TURNS NEURON INTO OSCILLATOR

Abstract

Recently, neurobiologists have discovered axons on neurons which synapse on the same neuron's dendrites — so-called autapses. It is not yet clear what functional significance autapses offer for neural behavior. This is an ideal case for using a physical simulation to investigate how an autapse alters the firing of a neuron. We simulated a neural basket cell via the Hodgkin–Huxley equations and implemented an autapse which feeds back onto the soma of the neuron. The behavior of the cell was compared with and without autaptic feedback. Our artificial autapse neuron (AAN) displays oscillatory behavior which is not observed for the same model neuron without autapse. The neuron oscillates between two functional states: one where it fires at high frequency and another where firing is suppressed. This behavior is called "spike bursting" and represents a common pattern recorded from cerebral neurons.