Vapor Toxicity of UDMH in Rats and Dogs From Short Exposures

Abstract

Abstract A study was made of the inhalation toxicity of UDMH in animals from single short exposures. Five- to sixty-minute exposure of dogs and rats to high concentrations of UDMH produce toxic signs similar to those resulting from longer inhalation exposures. No clinical abnormalities resulted from these single short-term exposures. Dogs exposed to 50, 200, and 600 ppm of UDMH for single or multiple periods of 60-, 15-, and 5-minute duration, respectively, showed no adverse physiological effects. These levels of UDMH can serve as a basis from which short-term exposure standards may be estimated for man. Dogs retained about 80 per cent of the inhaled UDMH.