Publication | Closed Access
Molecular Architecture with Functionalized β‐Peptide Helices
69
Citations
23
References
2003
Year
Protein AssemblyPeptide EngineeringMolecular BiologyPeptide ScienceFunctionalized β‐Peptide HelicesAnalytical Ultracentrifugationβ-Peptide OligomersProtein Foldingβ-Peptide HelicesMacromolecular AssembliesProtein ChemistryBiochemistryMolecular ModelingStructural BiologySpecific RecognitionNatural SciencesPeptide SynthesisMolecular BiophysicsMedicine
Specific recognition of β-peptide helices can be achieved by the incorporation of nucleo-β-amino acids in every third position of β-peptide oligomers. Pairing complexes (see picture) are formed with extraordinary high stabilities in aqueous buffer. A major contribution comes from the high preorganization of the nucleobases by the 14-helix backbone. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2003/z51871_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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