Evaluation of IFN-γ Serum Level in Nephropatic Type 2 Diabetic Patients

Abstract

The present study was aimed to examine the serum level of IFN-gamma in type 2 diabetic patients with nephropatic complications. In this experimental study, serum samples were obtained from 100 type 2 diabetic patients suffering from nephropathy and 100 healthy controls. Serum level of IFN-gamma was analyzed by ELISA. Results of this study showed that the mean serum level of IFN-gamma was 16.09 +/- 2.04 and 4.03 +/- 1.00 pg mL(-1) in nephropathic patients and healthy controls, respectively. Statistical analysis of data showed that the difference in the IFN-gamma serum level was significant between nephropathic patients and controls. Due to the elevated level of IFN-gamma in nephropathic patients, it can be possibly concluded that IFN-gamma is involved in nephropathy complication of type 2 diabetes.