Ocular antisense oligonucleotide delivery by cationic nanoemulsion for improved treatment of ocular neovascularization: An in-vivo study in rats and mice

Oxygen-induced retinopathy in the mouse.

Lois Elaine Hodgson Smith, Eva Wesolowski, Angela McLellan et al. · PubMed · 1994 · 1.6K citations · Full text

Medicine, Ophthalmology, Vision Science +16

Pharmacokinetics, biodistribution, and stability of oligodeoxynucleotide phosphorothioates in mice.

Sudhir Agrawal, Jamal Temsamani, Jin Tang · Proceedings of the National Academy of Sciences · 1991 · 560 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +11

Substrate Specificity and Kinetics of Degradation of Antisense Oligonucleotides by a 3′ Exonuclease in Plasma

Paul S. Eder, Rene J. DeVine, John M. Dagle et al. · Antisense Research and Development · 1991 · 291 citations

Life Sciences, Biochemistry, Molecular Biology +17

Biodistribution and metabolism of internally 3H-labeled oligonucleotides. I. Comparison of a phosphodiester and a phosphorothioate.

Howard Sands, Lorraine J. Gorey‐Feret, Anthony J. Cocuzza et al. · Molecular Pharmacology · 1994 · 268 citations

Pharmacy, Biochemistry, Pharmacokinetics +15

Disposition of the 14C-labeled phosphorothioate oligonucleotide ISIS 2105 after intravenous administration to rats.

Paul A. Cossum, Henri Sasmor, D Dellinger et al. · Journal of Pharmacology and Experimental Therapeutics · 1993 · 266 citations

Medicine, Pharmacokinetics, Pharmacology +12