Concepedia

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Assignment of CD38, the gene encoding human leukocyte antigen CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase), to chromosome 4p15

DOI

53

Citations

0

References

1995

Year

K. Nakagawara, Mitsuko Mori, Shin Takasawa, Koji Nata, Toshinari Takamura, A. Berlova, Akira Tohgo, Tadahiro Karasawa, Hideto Yonekura, T Takeuchi,
Cytogenetic and Genome Research

Abstract

CD38 has been used as a phenotype marker of lymphocyte differentiation. Recently, we have demonstrated that cyclic ADP-ribose can be synthesized and hydrolyzed by CD38 and acts as a second messenger in insulin secretion from pancreatic beta-cells. We have mapped the CD38 gene to human chromosome 4p15 by fluorescence in situ hybridization.