Biologically Programmed Nanoparticle Assembly

Abstract

The use of protein–substrate binding to program the self-assembly of nanoparticle-based structures from aqueous solution is highlighted here. The systems discussed include aqueous dispersions of metal nanoparticles with surface-attached antibodies and bivalent antigens in solution (see Figure), and ferritin-encapsulated metal oxide nanoparticles with surface biotin groups and streptavidin in solution.