Application of the obligate aerobic yeast Yarrowia lipolytica as a eucaryotic model to analyse Leigh syndrome mutations in the complex I core subunits PSST and TYKY

Prediction of protein conformation

Peter Y. Chou, Gerald D. Fasman · Biochemistry · 1974 · 3.3K citations

Life Sciences, Biochemistry, Bioinformatics +9

Blue native electrophoresis for isolation of membrane protein complexes in enzymatically active form

Hermann Schägger, Gebhard von Jagow · Analytical Biochemistry · 1991 · 2.2K citations

Life Sciences, Biochemistry, Molecular Biology +16

Leigh syndrome: Clinical features and biochemical and DNA abnormalities

S. Rahman, Rozanne B. Blok, H H Dahl et al. · Annals of Neurology · 1996 · 780 citations

Life Sciences, Genetics, Molecular Genetics +17

Mutation of a nuclear succinate dehydrogenase gene results in mitochondrial respiratory chain deficiency

Thomas Bourgeron, Pierre Rustin, Dominique Chrétien et al. · Nature Genetics · 1995 · 725 citations

Life Sciences, Genetics, Molecular Genetics +13

Heteroplasmic mtDNA mutation (T----G) at 8993 can cause Leigh disease when the percentage of abnormal mtDNA is high.

Y. Tatuch, John Christodoulou, Annette Feigenbaum et al. · PubMed · 1992 · 485 citations

Life Sciences, Genetics, Molecular Genetics +9