Synthesis leading to novel 2,4,6-trisubstituted quinazoline derivatives, their antibacterial and cytotoxic activity against THP-1, HL-60 and A375 cell lines

Abstract

., single compound able to interact with multiple altered pathogenetic pathways, for the multifactorial mechanistic nature of cancer cells, is of current interest. Following this rationale, we designed 4-long chain amino quinazolines, able to irreversibly block epidermal growth factor receptor (EGFR), and to induce apoptosis in tumor cell lines. Recent evidence also suggests that, combination therapy of cancer with receptor tyrosine kinase (RTK) inhibitors, are usually cytotoxic and conventional chemotherapeutic agents provide an improved treatment option. Several successful attempts have been recorded in literature demon-strating promising outcomes