Quinine as a chiral additive in nonaqueous capillary zone electrophoresis

Abstract

Quinine was used as a chiral additive in nonaqueous capillary zone electrophoresis. The separation buffer consisted of ammonium acetate and quinine in methanol. Quinine was able to enantioresolve a number of N-3,5-dinitrobenzoylated amino acids as well as (±)-1,1′-binaphthyl-2,2′diyl hydrogen phosphate and N-[1-(1-naphthyl)ethyl]phthalamic acid. Enantioresolution deteriorated as the concentration of ammonium acetate was increased but improved with the addition of acetic acid. Chiral recognition seems to arise through an ion-pairing mechanism. © 1996 John Wiley & Sons, Inc.