Modulation of the Biological Properties of Aspirin by Formation of a Bioorganometallic Derivative

Abstract

Beyond treating headaches: The derivatization of biologically active compounds by organometallic units modulates their pharmacological properties. In studies of antitumor-related biochemical properties, the Co2(CO)6 derivative of aspirin 1 shows significantly modified influence on several relevant pathways, which might be based on an altered interaction with the target enzyme COX-2. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.