Role for a bidentate ribonuclease in the initiation step of RNA interference

Emily Bernstein, Amy A. Caudy, Scott M. Hammond, +1

Nature

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The Microprocessor complex mediates the genesis of microRNAs

Richard I. Gregory, Kai-ping Yan, Govindasamy Amuthan, +4

Nature

GeneticsMicrorna DetectionSmall RnaGene ExpressionMedicine +3

Argonaute2 Is the Catalytic Engine of Mammalian RNAi

Jidong Liu, Michelle A. Carmell, Fabiola V. Rivas, +6

Science

EngineeringGeneticsCatalytic EngineRna BiologyMolecular Biology +9

TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing

Thimmaiah P. Chendrimada, Richard I. Gregory, Easwari Kumaraswamy, +4

Nature

Transcriptional RegulationDicer ComplexFunctional GenomicsMedicineGenetics +8

Regulation of Heterochromatic Silencing and Histone H3 Lysine-9 Methylation by RNAi

Thomas A. Volpe, Catherine Kidner, Ira M. Hall, +3

Science

Human Argonaute2 Mediates RNA Cleavage Targeted by miRNAs and siRNAs

Gunter Meister, Markus Landthaler, Agnieszka Patkaniowska, +3

Molecular Cell

Natural SciencesMedicineRna BiologyMolecular BiologyMicrorna Detection +5

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5

Hiroki Kato, Osamu Takeuchi, Eriko Mikamo-Satoh, +7

The Journal of Experimental Medicine

Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing

Chryssa Kanellopoulou, Stefan A. Muljo, Andrew L. Kung, +5

Genes & Development

Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes

Toshiaki Watanabe, Yasushi Totoki, Atsushi Toyoda, +10

Nature

Developmental BiologyRna BiologyEndogenous SirnasDsrnas Regulate TranscriptsSmall Rna +5

Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes

Oliver H. Tam, Alexei A. Aravin, Paula Stein, +8

Nature

Developmental BiologyGeneticsRna BiologySmall RnaGene Expression +5