Clinical Nephrology · 2006 · 23 citations · 0 references
MedicineInternal MedicineNephrologyHepatologyRenal PathologyRenal PharmacotherapyGlomerular DiseasesImmune-mediated Renal DiseaseNephrotic SyndromeRenal DiseaseViral HepatitisViral Hepatitis TreatmentChronic Viral HepatitisGlomerular HistopathologyHepatitis B TherapyLamivudine TherapyMembranous Nephropathy TherapyNephrotic Syndrome TreatmentRenal Biopsy DiagnosisRenal Biopsy Findings
We present a case of chronic hepatitis B with membranous nephropathy, that was improved by lamivudine treatment. A 37-year-old man was admitted to our hospital for the evaluation of proteinuria. He was diagnosed as having chronic glomerulonephritis associated with chronic hepatitis B. Histopathological findings of the renal biopsy specimen indicated membranous nephropathy. He suffered from nephrotic syndrome associated with leg edema, which was parallel to the exacerbation of hepatitis. Lamivudine was started for the treatment of hepatitis, which caused the disappearance of serum hepatitis B virus DNA and the normalization of ALT level in 4 weeks. Additionally, proteinuria disappeared 120 weeks after the treatment was started. Lamivudine treatment may remit HBV-associated nephropathy.