Synthesis · 2006 · 66 citations · 0 references
Effective MethodologyPyridinium YlidesOrganic ChemistryOne-pot ProcessSynthetic ChemistryStereoselective SynthesisChemistryHeterocycle ChemistrySynthesis MethodNatural Product SynthesisPyridinium SaltsEnantioselective Synthesis
A new method for the synthesis of 2,3-dihydrofurans from readily available starting enones and pyridinium salts has been developed. This protocol can provide a novel and effective methodology for the preparation of 2,3-dihydrofurans in a stereoselective fashion. To increase the efficiency of this reaction the one-pot process was also developed, in which the pyridinium salts were generated in situ from corresponding halides.