Science · 1985 · 63 citations · 18 references
Life SciencesMolecular BiologyMolecular GeneticsMolecular VirologyTranscriptionVirologyViral Gene ExpressionViral GeneticsViral Genome OrganizationViral InfectionsViral Rna BiologyViral TranscriptionMessenger Rna TranscriptionRetroviral TranscriptionRetrovirus BiologyRibonucleic Acid Virus TranscriptionViral Mrna PolyadenylationViral Open Reading FramesViral Polyadenylation SignalsViral Rna Polyadenylation
The retrovirus frequently isolated from patients with the acquired immune deficiency syndrome (AIDS) has two novel open reading frames previously designated "A" and "B." The "A" region was found to be specifically expressed as polyadenylated RNA's of 5.5 and 5.0 kilobases in infected cells. The "B" region was expressed as 1.8- to 2.0-kilobase RNA species. Additional full-length and spliced messenger RNA's of the env region were also identified.
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