Electroanalysis of Benazepril Hydrochloride Antihypertensive Drug Using an Ionic Liquid Crystal Modified Carbon Paste Electrode

Abstract

Abstract Electroanalysis of benazepril HCl was successful using a carbon paste electrode modified with an ionic liquid crystal ( 1‐butyl‐1‐methylpiperidinium hexafluorophosphate) in presence of sodium dodecyl sulfate. The electrode performance was compared to ionic liquids (1‐ n ‐hexyl‐3‐methyl imidazolium tetrafluoroborate and 1‐butyl‐4‐methyl pyridinium tetrafluoroborate). Electrochemical determination of benazepril HCl was in the linear dynamic range of 8.89×10 −7 to 1.77×10 −5 mol L −1 (correlation coefficient 0.999) and LOD 7.17×10 −9 mol L −1 . benazepril HCl was determined using this sensor in presence of urine metabolites such as uric acid, ascorbic acid. Binary mixtures of dopamine/benazepril and amlodipine/benazepril were also determined successfully.