Endotoxin tolerance in human intrahepatic biliary epithelial cells is induced by upregulation of IRAK‐M

Abstract

This study showed that the mechanism of endotoxin tolerance exists in the intrahepatic biliary tree and is possibly induced by the expression of IRAK-M in the intrahepatic biliary epithelium, suggesting that the endotoxin tolerance is important in maintaining innate immune biliary homeostasis.