Identification and Analysis of the Core Biosynthetic Machinery of Tubulysin, a Potent Cytotoxin with Potential Anticancer Activity

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

Julie Thompson, Desmond G. Higgins, Toby J. Gibson · Nucleic Acids Research · 1994 · 64.9K citations · Full text

Life Sciences, Bioinformatics, Sequence Analysis +14

The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases

Torsten Stachelhaus, Henning D. Mootz, Mohamed A. Marahiel · Chemistry & Biology · 1999 · 1.2K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +10

Structural organization of microcystin biosynthesis in Microcystis aeruginosa PCC7806: an integrated peptide–polyketide synthetase system

Daniel Tillett, Elke Dittmann, Marcel Erhard et al. · Chemistry & Biology · 2000 · 997 citations · Full text

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Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action

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Pharmacy, Medicinal Chemistry, Pharmacology +10

Modular Organization of Genes Required for Complex Polyketide Biosynthesis

Stefano Donadio, Michael J. Staver, James B. McAlpine et al. · Science · 1991 · 909 citations

Life Sciences, Biochemistry, Molecular Genetics +17