A Phenol Quaternary Ammonium Porphyrin as a Potent Telomerase Inhibitor by Selective Interaction with Quadruplex DNA

Abstract

Not adding anything new? Phenol quaternary ammonium derivatives have been found to cross-link DNA efficiently. Experimental data indicate that a phenol quaternary ammonium cationic porphyrin (TQMP) potently inhibits a telomerase (IC50=1.7 μM) due to its selective, stabilizing interactions with G-quadruplexes. These interactions might derive from the greater flexibility of TQMP over pyridinium porphyrins and its steric effect. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2268/2006/z600036_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.