Acute Localized Exanthematous Pustulosis on Inguinal Area Secondary to Piperacillin/tazobactam

Abstract

Acute generalized exanthematous pustulosis (AGEP) is a rare but well-known cutaneous reaction pattern mostly caused by drugs, i.e. aminopenicillins. Fever and erythema, followed by numerous tiny non-follicular pustules that usually appear within days after administering the medication, are characteristic. The reaction is self-limiting once the causative drug is withdrawn. The pathomechanisms of AGEP remain uncertain, but there is some evidence of underlying T-cell mediated process (1).