Enantioselective Aza‐Henry Reaction with Acyclic Guanidine‐Thiourea Bifunctional Organocatalyst

Abstract

Abstract magnified image A highly enantioselective aza‐Henry reaction of imines with nitromethane was achieved with a reactive guanidine‐thiourea bifunctional organocatalyst affording β‐nitroamines with high enantioselectivity (up to 96% ee ). The diastereo‐ and enantioselective version of this reaction with nitroalkanes also proceeded selectively (up to 99:1 dr with 99% ee ).