Pyranonigrin E: A PKS‐NRPS Hybrid Metabolite from <i>Aspergillus niger</i> Identified by Genome Mining

Abstract

Induced production of PKS-NRPS metabolites: the genome mining approach is useful for obtaining new compounds. We activated a dormant PKS-NRPS gene cluster in Aspergillus niger ATCC 1015 by expressing its dedicated transcriptional activator (PynR). As a result, the transformant expressing pynR produced a new pyranonigrin compound that we have named pyranonigirin E.