Site of Action of Angiotensin and other Vasoconstrictors on the Kidney

Abstract

Angiotensin II, angiotensin I, adrenaline, or noradrenaline was infused in rabbit kidneys isolated and perfused with oxygenated Krebs solution. Adrenaline increased the perfusion pressure and slightly decreased the filtration fraction and the glomerular filtration rate. Angiotensins had similar effects on the perfusion pressure, but significantly increased filtration fraction and glomerular filtration rate.It is suggested that adrenaline acts on the afferent, while angiotensins II and I constrict the efferent, glomerular artery.