Blood–brain barrier dysfunction following traumatic brain injury: correlation of K^trans(DCE-MRI) and SUVR (99mTc-DTPA SPECT) but not serum S100B

Abstract

The correlation of SPECT with DCE-MRI suggests that either scan may be used to assess post-traumatic BBB damage. We could not support serum S100B to be an accurate measure of BBB damage when sampled a number of days following injury but the small number of patients, the heterogeneity in TBI patients and the delay following injury makes any firm conclusions regarding S100B and BBB difficult.