Bone Marrow-Derived Stem Cells Attenuate Impaired Contractility and Enhance Capillary Density in a Rabbit Model of Doxorubicin-Induced Failing Hearts

Abstract

Despite local cell transplantation, autologous BMCs improve global contractility and enhance remote capillary density and collagen content in doxorubicin-induced cardiomyopathy. However, BMCs failed to transdifferentiate into new cardiomyocytes.