Oxidation of Primary Amines to <i>N</i>‐Monoalkylhydroxylamines using Sodium Tungstate and Hydrogen Peroxide‐Urea Complex

Abstract

Abstract The sodium tungstate‐catalyzed (10 mol %) oxidation of primary amines with a urea‐hydrogen peroxide complex (UHP) gives the corresponding N ‐monoalkylhydroxylamines, which are important biologically active compounds, in good to excellent yields. The method is applicable for a wide range of primary amines, including chiral benzylic amines, α‐1,2‐hydroxylamine and α‐amino esters.