Triphenylphosphine-Catalyzed Nucleophilic α-Addition to Alkyl Propiolates Synthesis of α-Substituted Alkyl Acrylates

Abstract

The f -addition of NH-acids such as pyrrole, indole, imidazole, or benzimidazole to methyl or ethyl propiolate proceeds under neutral conditions in the presence of a catalytic amount of triphenylphosphine to give the corresponding f -substituted alkyl acrylates.