Immunohistochemical Demonstration of Advanced Glycation End Products and the Effects of Advanced Glycation End Products in Ossified Ligament Tissues In Vitro

Abstract

This is the first report to investigate the correlation, if any, between the ossified spinal ligament and advanced glycation end products. These results suggested that accumulation in advanced glycation end products and their interaction with advanced glycation end product receptor were 1 of the important risk factors in the process of ossification in the spinal ligaments.