Asymmetric Friedel−Crafts Addition of Indoles to <i>N</i>-Sulfonyl Aldimines: A Simple Approach to Optically Active 3-Indolyl-methanamine Derivatives

Abstract

[reaction: see text] The enantioselective copper(II)-catalyzed Friedel-Crafts addition of indoles to N-sulfonyl aldimines was developed using chiral bisoxazoline as ligands, and high enantioselectivities (up to 96% ee) were achieved.