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Chromosomal Autoradiography in the <i>Cri du Chat</i> Syndrome
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1964
Year
CytogeneticsGeneticsPathologyMolecular BiologyMolecular GeneticsDna SynthesisChromosome 22RadiologyGenome InstabilityHistopathologyMeiosisDna ReplicationChromosomal AutoradiographyExtensive Late ReplicationChromosomal RearrangementMosaicismChromatinChromosome DynamicsChromatin StructureAbnormal ChromosomeGenetic DisorderNatural SciencesChromosome BiologyMedicineChromosome 9
The pattern of DNA synthesis in the chromosomes of Group 4–5 has been analysed in cells from individuals with the <i>cri du chat </i>syndrome. The abnormal chromosome, a No. 5, is one of the pair characterized by relatively early completion of synthesis in the long arms. The two remaining members of this group, characterized by extensive late replication throughout their lengths, therefore may now be recognized as the Nos. 4.