Closed-Loop Artificial Pancreas Using Subcutaneous Glucose Sensing and Insulin Delivery and a Model Predictive Control Algorithm: The Virginia Experience

Abstract

Model predictive closed-loop control of BG levels can be achieved overnight and following a standardized breakfast meal. This "artificial pancreas" controls BG levels as effectively as patient-directed open-loop control following a morning meal but is significantly superior to open-loop control in preventing overnight hypoglycemia.