Testing the Statistical Certainty of a Response to Increasing Doses of a Drug

Abstract

Experiments in which the treatments are composed of a series of doses of a compound and a zero dose control are often used in animal toxicity studies. A test procedure is proposed to assess trends in the response variable. The notion of a no-statistical-significance-of-trend (NOSTASOT) dose is introduced, and questions of multiplicity of statistical tests in this context are addressed.