Copper‐Catalyzed <i>N</i>‐Arylation of Hindered Substrates Under Mild Conditions

Abstract

Abstract magnified image A mild, efficient method utilizing a copper‐diamine catalyst at room temperature is reported for the coupling of hindered imidazoles with unsubstituted, ortho‐ substituted, and bis‐ ortho ‐substituted boronic acids in good to excellent yields. Aryl halides do not reaction under these conditions permitting sequential N ‐arylation reactions.