Journal of the American Chemical Society · 2008 · 284 citations · 23 references
Natural SciencesChemistryMedicinal ChemistryCatalysisOrganic ChemistrySynthetic Medicinal ChemistryOrganic SynthesisAsymmetric SynthesisBrønsted Acid CatalysisBrønsted AcidityCatalytic SynthesisDirect SynthesisEnantioselective Synthesis
A highly enantioselective Brønsted acid catalyzed direct synthesis of cyclic aminals from aldehydes has been developed. The methodology has been applied to the first asymmetric synthesis of several antihypertensive aminal drugs including (R)-Thiabutazide.
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Enantioselective Organocatalytic Reductive Amination
Richard Storer, Diane E. Carrera, Yike Ni et al. · Journal of the American Chemical Society · 2005 · 731 citations